Rapid and Reproducible Deactivation of Rhodopsin Requires Multiple Phosphorylation Sites

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Rapid and Reproducible Deactivation of Rhodopsin Requires Multiple Phosphorylation Sites

Efficient single-photon detection by retinal rod photoreceptors requires timely and reproducible deactivation of rhodopsin. Like other G protein-coupled receptors, rhodopsin contains multiple sites for phosphorylation at its COOH-terminal domain. Transgenic and electrophysiological methods were used to functionally dissect the role of the multiple phosphorylation sites during deactivation of rh...

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Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light.

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ژورنال

عنوان ژورنال: Neuron

سال: 2000

ISSN: 0896-6273

DOI: 10.1016/s0896-6273(00)00093-3